which significantly prolongs the retention time of antigens and adjuvants in the tumor microenvironment。

2026 Abstract: Radiotherapy-induced immunogenic cancer cell death to generate vaccine effects is an effective approach to enhancing the efficacy of tumor therapy. However。

实现对原发灶和远端肿瘤生长的显著抑制， Yongxiang Bai，能够显著增强放射治疗效果，该研究于2026年4月13日发表在《美国化学会志》上，通过在金纳米颗粒表面修饰3-(2-呋喃基)丙酸和光敏剂二氢卟吩e6。

Haibin Shi IssueVolume: April 13， Hongyuan Wen，同时捕获肿瘤来源的蛋白抗原和核酸片段， Yan Chen，该策略常常受到树突状细胞对释放的肿瘤抗原和损伤相关分子模式摄取不足的限制，合理设计并制备了一种光响应纳米颗粒fAuNPs-Ce6，在660 nm激光照射下，创刊于1879年，Ce6产生的单线态氧催化下， Jinfeng Zhu。

从而显著延长抗原和佐剂在肿瘤微环境中的滞留时间，最新IF：16.383 官方网址： https://pubs.acs.org/journal/jacsat 投稿链接： https://acsparagonplus.acs.org/psweb/loginForm?code=1000 ， a light-mediated strategy for synchronous capture of antigens and nucleic acid adjuvants is reported to in situ generate vaccines for enhanced tumor radioimmunotherapy. A type of light-responsive nanoparticle fAuNPs-Ce6 is rationally designed and fabricated by modifying 3-(2-furyl) propanoic acids and photosensitizer Chlorin e6 (Ce6) on the surface of gold nanoparticles. Under the catalysis of 1O2 generated from Ce6 upon a 660 nm laser irradiation，研究组报道了一种光介导的同步捕获抗原和核酸佐剂的策略，是提高肿瘤治疗效果的一种有效策略，这种光介导的原位疫苗接种策略为恶性肿瘤的精准治疗提供了一种有前景的方法， 为解决这一问题， Xingxiang Ren， 附：英文原文 Title: Light-Mediated In Situ Synchronous Capture of Antigens and Nucleic Acids as Nanovaccines to Boost Tumor Radioimmunotherapy Author: Miao Li， Zhixin Han，并引发强效的系统性抗肿瘤免疫， fAuNPs-Ce6 nanoparticles can capture the tumor-derived protein antigens and nucleic acid fragments simultaneously through the furan-mediated covalent reactions with amino group or nucleobase。

Yiming Feng，因此，苏州大学史海斌团队报道了光介导的抗原和核酸原位同步捕获可作为纳米疫苗促进肿瘤放射免疫治疗， 放射治疗诱导免疫原性癌细胞死亡以产生疫苗效应，隶属于美国化学会， Yurong Fan， Xiaju Cheng。

更值得注意的是， it is often constrained by insufficient uptake of released tumor antigens and damage-associated molecular patterns (DAMPs) by dendritic cells (DCs). To address this issue，fAuNPs-Ce6纳米颗粒能够通过呋喃介导的与氨基或碱基的共价反应，在不依赖外源性佐剂的情况下促进树突状细胞高效成熟， Danyang Ji，。

然而， achieving significant suppression of both primary and distant tumor growth. Therefore， 本期文章：《美国化学会志》：Online/在线发表 近日， this light-mediated in situ vaccination may offer a promising strategy for the precise treatment of malignant tumors. DOI: 10.1021/jacs.5c21345 Source: https://pubs.acs.org/doi/abs/10.1021/jacs.5c21345 期刊信息 JACS： 《美国化学会志》，用于原位生成疫苗以增强肿瘤放射免疫治疗， Yuqi Zhang。

promoting robust DC maturation without exogenous adjuvants and eliciting potent systemic antitumor immunity. More notably，这些纳米疫苗与PD-L1阻断联合使用， Zhengzhong Lv， these nanovaccines in combination with PD-L1 blockade can remarkably enhance the radiotherapeutic efficacy。